Genetic architecture of hippocampus subfields volumes in Alzheimer's disease.

ABSTRACT:

Background

The hippocampus is a heterogeneous structure, comprising histologically and functionally distinguishable hippocampal subfields. The volume reductions in hippocampal subfields have been demonstrated to be linked with Alzheimer's disease (AD). The aim of our study is to investigate the hippocampal subfields' genetic architecture based on the Alzheimer's Disease Neuroimaging Initiative (ADNI) data set.

Methods

After preprocessing the downloaded genetic variants and imaging data from the ADNI database, a co-sparse reduced rank regression model was applied to analyze the genetic architecture of hippocampal subfields volumes. Homology modeling, docking, molecular dynamics simulations, and Co-IP experiments for protein-protein interactions were used to verify the functio

SUBMITTER: Cai J 

PROVIDER: S-EPMC10915996 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature