Contribution of small airway inflammation to the development of COPD.

ABSTRACT:

Background

Little attention has been paid to the pathophysiological changes in the natural history of chronic obstructive pulmonary disease (COPD). The destructions of the small airways were visualized on thoracic micro-computed tomography scan. We investigated whether small airway inflammation (SAI) was the risk for the development of COPD.

Methods

A total of 1062 patients were enrolled and analyzed in the study. The partitioned airway inflammation was determined by exhaled nitric oxide (NO) of FnNO, FeNO₅₀, FeNO₂₀₀, and calculated CaNO_dual. Both FeNO₂₀₀ and CaNO_dual were compared to detect the promising predictor for peripheral airway/alveolar inflammation in COPD. The correlation between exhaled NO and white cell clas

SUBMITTER: Li L 

PROVIDER: S-EPMC10916214 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature