MORN2 regulates the morphology and energy metabolism of mitochondria and is required for male fertility in mice.

ABSTRACT:

Background

Mitochondria produce adenosine triphosphate through respiratory activities to power sperm differentiation and motility, and decreased mitochondrial respiratory activity can result in poor sperm motility and asthenospermia. The mitochondrial sheath is a component of the mid-piece of the sperm flagellum, and dysfunction of the sheath can reduce sperm motility and cause male infertility. The membrane occupation and recognition nexus-motif protein 2 (MORN2) is testis enriched in mice, and the MORN motif was reported to play a role in the regulation of bioelectrical signal homeostasis in cardiomyocytes.

Methods

We generated Morn2^-/- mice using CRISPR/Cas9 and evaluated the potential functions of MORN2 in spermiogenesis through histological analysis, fertilit

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10916217 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature