Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade.

ABSTRACT:

Background

Tumor regression following immune checkpoint blockade (ICB) is often associated with immune-related adverse events (irAEs), marked by inflammation in non-cancerous tissues. This study was undertaken to investigate the functional relationship between anti-tumor and anti-self immunity, to facilitate irAE management while promoting anti-tumor immunity.

Methods

Multiple biopsies from tumor and inflamed tissues were collected from a patient with melanoma experiencing both tumor regression and irAEs on ICB, who underwent rapid autopsy. Immune cells infiltrating melanoma lesions and inflamed normal tissues were subjected to gene expression profiling with multiplex qRT-PCR for 122 candidate genes. Subsequently, immunohistochemistry was conducted to assess the expression o

SUBMITTER: Chen S 

PROVIDER: S-EPMC10916264 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature