Sensitizing methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) to cefuroxime: the synergic effect of bicarbonate and the wall teichoic acid inhibitor ticlopidine.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) strains are a major challenge for clinicians due, in part, to their resistance to most β-lactams, the first-line treatment for methicillin-susceptible S. aureus. A phenotype termed "NaHCO₃-responsiveness" has been identified, wherein many clinical MRSA isolates are rendered susceptible to standard-of-care β-lactams in the presence of physiologically relevant concentrations of NaHCO₃, in vitro and ex vivo; moreover, such "NaHCO₃-responsive" isolates can be effectively cleared by β-lactams from target tissues in experimental infective endocarditis (IE). One mechanistic impact of NaHCO₃ exposure on NaHCO₃-responsive MRSA is to repress WTA synthesis. This NaHCO<

SUBMITTER: Ersoy SC 

PROVIDER: S-EPMC10916381 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature