Global genetic diversity and Asian clades evolution: a phylogeographic study of <i>Staphylococcus aureus</i> sequence type 5.

ABSTRACT: Staphylococcus aureus sequence type (ST) 5 has spread worldwide; however, phylogeographic studies on the evolution of global phylogenetic and Asian clades of ST5 are lacking. This study included 368 ST5 genome sequences, including 111 newly generated sequences. Primary phylogenetic analysis suggested that there are five clades, and geographical clustering of ST5 methicillin-resistant S. aureus (MRSA) was linked to the acquisition of S. aureus pathogenicity islands (SaPIs; enterotoxin gene island) and integration of the prophage φSa3. The most recent common ancestor of global S. aureus ST5 dates back to the mid-1940s, coinciding with the clinical introduction of penicillin. Bayesian phylogeographic inference allowed to ancestrally trace the Asian ST5 MRSA clade t

SUBMITTER: Chen F 

PROVIDER: S-EPMC10916392 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature