SERPINA3: A novel inflammatory biomarker associated with cerebral small vessel disease burden in ischemic stroke.

ABSTRACT:

Background and objective

Inflammation has emerged as a prominent risk factor for cerebral small vessel disease (CSVD). However, the specific association between various inflammatory biomarkers and the development of CSVD remains unclear. Serine proteinase inhibitor A3 (SERPINA3), Matrix metalloproteinase-9 (MMP-9), Tissue inhibitor metalloproteinase-1 (TIMP-1), Monocyte Chemoattractant Protein-1 (MCP-1) are several inflammatory biomarkers that are potentially involved in the development of CSVD. In this present study, we aimed to investigate the relationship between candidate molecules and CSVD features.

Method

The concentration of each biomarker was measured in 79 acute ischemic stroke patients admitted within 72 h after symptom onset. The associations between blood levels

SUBMITTER: Hu X 

PROVIDER: S-EPMC10916418 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature