Serum Bile Acids Improve Prediction of Alzheimer's Progression in a Sex-Dependent Manner.

ABSTRACT: Sex disparities in serum bile acid (BA) levels and Alzheimer's disease (AD) prevalence have been established. However, the precise link between changes in serum BAs and AD development remains elusive. Here, authors quantitatively determined 33 serum BAs and 58 BA features in 4 219 samples collected from 1 180 participants from the Alzheimer's Disease Neuroimaging Initiative. The findings revealed that these BA features exhibited significant correlations with clinical stages, encompassing cognitively normal (CN), early and late mild cognitive impairment, and AD, as well as cognitive performance. Importantly, these associations are more pronounced in men than women. Among participants with progressive disease stages (n = 660), BAs underwent early changes in men, occurring before AD. By incor

SUBMITTER: Chen T 

PROVIDER: S-EPMC10916590 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature