Hemodynamic significance of intracranial atherosclerotic disease and ipsilateral imaging markers of cerebral small vessel disease.

ABSTRACT:

Introduction

Cerebral small vessel disease (CSVD) commonly exists in patients with symptomatic intracranial atherosclerotic disease (sICAD). We aimed to investigate the associations of hemodynamic features of sICAD lesions with imaging markers and overall burden of CSVD.

Patients and methods

Patients with anterior-circulation sICAD (50%-99% stenosis) were analyzed in this cross-sectional study. Hemodynamic features of a sICAD lesion were quantified by translesional pressure ratio (PR = Pressure_{post-stenotic}/Pressure_pre-stenotic) and wall shear stress ratio (WSSR = WSS_{stenotic-throat}/WSS_pre-stenotic) via CT angiography-based computational fluid dynamics modeling. PR ⩽median was defined as low ("abnormal") PR, and WSSR ⩾ fourth quart

SUBMITTER: Zheng L 

PROVIDER: S-EPMC10916816 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature