Biological variation estimates of Alzheimer's disease plasma biomarkers in healthy individuals.

ABSTRACT:

Introduction

Blood biomarkers have proven useful in Alzheimer's disease (AD) research. However, little is known about their biological variation (BV), which improves the interpretation of individual-level data.

Methods

We measured plasma amyloid beta (Aβ42, Aβ40), phosphorylated tau (p-tau181, p-tau217, p-tau231), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) in plasma samples collected weekly over 10 weeks from 20 participants aged 40 to 60 years from the European Biological Variation Study. We estimated within- (CV_I ) and between-subject (CV_G ) BV, analytical variation, and reference change values (RCV).

Results

Biomarkers presented considerable variability in CV_I and CV_G . Aβ42/Aβ40 had the l

SUBMITTER: Brum WS 

PROVIDER: S-EPMC10916965 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature