Diversification of immunoglobulin genes by gene conversion in the domestic chicken (Gallus gallus domesticus).

ABSTRACT: Sustainable modern poultry production depends on effective protection against infectious diseases and a diverse range of antibodies is key for an effective immune response. In the domestic chicken, somatic gene conversion is the dominant process in which the antibody immunoglobulin genes are diversified. Affinity maturation by somatic hypermutation (SHM) also occurs, but the relative contribution of gene conversion versus somatic hypermutation to immunoglobulin (Ig) gene diversity is poorly understood. In this study, we use high throughput long-read sequencing to study immunoglobulin diversity in multiple immune-associated tissues in Rhode Island Red chickens. To better understand the impact of genetic diversification in the chicken, a novel gene conversion identification software was deve

SUBMITTER: Mallaby J 

PROVIDER: S-EPMC10917233 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature