Project description:Human and swine cardiac tissue samples collected from healthy controls treated with popular transplant organ preservative (Histidine-tryptophan-ketoglutarate, HTK) OR an experimental transplant organ preservative (cocktail of HTK and canrenone) to compare preservative effectiveness. Includes both positive and negative data collection for each of the metabolomic and lipidomic datasets.

2024-12-30 | MSV000096745 | MassIVE

Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.

Project description: Not available

| S-EPMC10077489 | biostudies-literature

Aldosterone-inducible genes in mineralocorticoid receptor expressed human endothelial cell lines

Project description:To elucidate the aldosterone-regulated genes in vascular endothelial cells, we developed human endothelial cell line (EAhy926) stably expressing human mineralocorticoid receptor by retroviral system (MR-EAhy). Then gene expression profile of MR-EAhy stimulated with or without aldosterone was compared using DNA microarray analysis. MR-EAhy were serum-deprived for 24h with 0.2% dextran-coated charcoal-treated FBS, and then stimulated with or without aldosterone (10-9 M) for 6 hr. Then cells were harvested for RNA extraction.

2011-03-18 | E-GEOD-28009 | biostudies-arrayexpress