Genetic determinants of micronucleus formation in vivo.

ABSTRACT: Genomic instability arising from defective responses to DNA damage¹ or mitotic chromosomal imbalances² can lead to the sequestration of DNA in aberrant extranuclear structures called micronuclei (MN). Although MN are a hallmark of ageing and diseases associated with genomic instability, the catalogue of genetic players that regulate the generation of MN remains to be determined. Here we analyse 997 mouse mutant lines, revealing 145 genes whose loss significantly increases (n = 71) or decreases (n = 74) MN formation, including many genes whose orthologues are linked to human disease. We found that mice null for Dscc1, which showed the most significant increase in MN, also displayed a range of phenotypes characteristic of patients with cohesinopathy disorders. After val

SUBMITTER: Adams DJ 

PROVIDER: S-EPMC10917660 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature