Ripple-locked coactivity of stimulus-specific neurons and human associative memory.

ABSTRACT: Associative memory enables the encoding and retrieval of relations between different stimuli. To better understand its neural basis, we investigated whether associative memory involves temporally correlated spiking of medial temporal lobe (MTL) neurons that exhibit stimulus-specific tuning. Using single-neuron recordings from patients with epilepsy performing an associative object-location memory task, we identified the object-specific and place-specific neurons that represented the separate elements of each memory. When patients encoded and retrieved particular memories, the relevant object-specific and place-specific neurons activated together during hippocampal ripples. This ripple-locked coactivity of stimulus-specific neurons emerged over time as the patients' associative learning pro

SUBMITTER: Kunz L 

PROVIDER: S-EPMC10917673 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature