Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [¹¹C]SMW139 and [¹⁸F]F-DPA.

ABSTRACT:

Background

P2X7 receptor has emerged as a potentially superior PET imaging marker to TSPO, the gold standard for imaging glial reactivity. [¹¹C]SMW139 is the most recently developed radiotracer to image P2X7 receptor. The aim of this study was to image reactive glia in the APP/PS1-21 transgenic (TG) mouse model of Aβ deposition longitudinally using [¹¹C]SMW139 targeting P2X7 receptor and to compare tracer uptake to that of [¹⁸F]F-DPA targeting TSPO at the final imaging time point. TG and wild type (WT) mice underwent longitudinal in vivo PET imaging using [¹¹C]SMW139 at 5, 8, 11, and 14 months, followed by [¹⁸F]F-DPA PET scan only at 14 months. In vivo imaging results were verified by ex vivo brain autoradiography, immunohistoc

SUBMITTER: Alzghool OM 

PROVIDER: S-EPMC10917722 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature