Exosomal small RNA profiling in first-trimester maternal blood explores early molecular pathways of preterm preeclampsia.

ABSTRACT:

Introduction

Preeclampsia (PE) is a severe obstetrical syndrome characterized by new-onset hypertension and proteinuria and it is often associated with fetal intrauterine growth restriction (IUGR). PE leads to long-term health complications, so early diagnosis would be crucial for timely prevention. There are multiple etiologies and subtypes of PE, and this heterogeneity has hindered accurate identification in the presymptomatic phase. Recent investigations have pointed to the potential role of small regulatory RNAs in PE, and these species, which travel in extracellular vesicles (EVs) in the circulation, have raised the possibility of non-invasive diagnostics. The aim of this study was to investigate the behavior of exosomal regulatory small RNAs in the most severe subtype of PE w

SUBMITTER: Gal L 

PROVIDER: S-EPMC10917917 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature