Adaptor protein complex 2 in the orbitofrontal cortex predicts alcohol use disorder.

ABSTRACT: Alcohol use disorder (AUD) is a life-threatening disease characterized by compulsive drinking, cognitive deficits, and social impairment that continue despite negative consequences. The inability of individuals with AUD to regulate drinking may involve functional deficits in cortical areas that normally balance actions that have aspects of both reward and risk. Among these, the orbitofrontal cortex (OFC) is critically involved in goal-directed behavior and is thought to maintain a representation of reward value that guides decision making. In the present study, we analyzed post-mortem OFC brain samples collected from age- and sex-matched control subjects and those with AUD using proteomics, bioinformatics, machine learning, and reverse genetics approaches. Of the 4,500+ total unique protei

SUBMITTER: Mulholland PJ 

PROVIDER: S-EPMC10918038 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature