Dysregulation of miRNA-mRNA expression in fetal growth restriction in a caloric restricted mouse model.

ABSTRACT: Fetal growth restriction (FGR) is associated with aberrant placentation and accounts for a significant proportion of perinatal deaths. microRNAs have been shown to be dysregulated in FGR. The purpose of this study was to determine microRNA-regulated molecular pathways altered using a caloric restricted mouse model of FGR. Pregnant mice were subjected to a 50% caloric restricted diet beginning at E9. At E18.5, RNA sequencing of placental tissue was performed to identify differences in gene expression between caloric restricted and control placentas. Significant differences in gene expression between caloric restricted and control placentas were observed in 228 of the 1546 (14.7%) microRNAs. Functional analysis of microRNA-mRNA interactions demonstrated enrichment of several biological pathw

SUBMITTER: Gallagher LT 

PROVIDER: S-EPMC10918062 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature