Screening sensibility and antifungal activity after topical application of a synthetic lactoferrin-derived antimicrobial peptide.

ABSTRACT:

Objective

Onychomycosis is the most common disease of the nails and constitutes about half of all nail abnormalities. Onychomycosis is usually caused by dermatophytes and incomparably less frequently by yeast-like fungi and non-dermatophyte molds. Current treatment options for onychomycosis are ineffective.

Methods

This study evaluated the performance of a commercial and CE-registered product containing antimicrobial peptide hLF1-11 in vitro for treating toenail onychomycosis. In a case-control setting, nail samples from 59 volunteers were obtained before and after treatment by a pedicurist and investigated for the presence of fungi by culturing, barcode sequencing, and MALDI-TOF-MS.

Results

Of 89 samples, T. rubrum (19%) and C. parapsilosis (17%) were c

SUBMITTER: Brouwer C 

PROVIDER: S-EPMC10918136 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature