Dynamic contrast optical coherence tomography (DyC-OCT) for label-free live cell imaging.

ABSTRACT: Dynamic contrast optical coherence tomography (DyC-OCT), an emerging imaging method, utilizes fluctuation patterns in OCT signals to enhance contrast, thereby enabling non-invasive label-free volumetric live cell imaging. In this mini review, we explain the core concepts behind DyC-OCT image formation and its system configurations, serving as practical guidance for future DyC-OCT users. Subsequently, we explore its applications in delivering high-quality, contrast-enhanced images of cellular morphology, as well as in monitoring changes in cellular activity/viability assay experiments.

SUBMITTER: Ren C 

PROVIDER: S-EPMC10918170 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature