Bring the pain: wounding reveals a transition from cortical excitability to epithelial excitability in Xenopus embryos.

ABSTRACT: The cell cortex plays many critical roles, including interpreting and responding to internal and external signals. One behavior which supports a cell's ability to respond to both internal and externally-derived signaling is cortical excitability, wherein coupled positive and negative feedback loops generate waves of actin polymerization and depolymerization at the cortex. Cortical excitability is a highly conserved behavior, having been demonstrated in many cell types and organisms. One system well-suited to studying cortical excitability is Xenopus laevis, in which cortical excitability is easily monitored for many hours after fertilization. Indeed, recent investigations using X. laevis have furthered our understanding of the circuitry underlying cortical excitability and ho

SUBMITTER: Sepaniac LA 

PROVIDER: S-EPMC10918254 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature