Dataset Information

Pesticide Nanoformulations Based on Sunlight-Activated Controlled Release of Abamectin.

ABSTRACT: A controlled release system that enables the sunlight-triggered release of a model agrochemical, abamectin (abm), is presented. The release system consists of polydopamine functionalized halloysite nanotubes (HNT-PDA) utilized as photothermal nanocarriers to encapsulate 25 wt % abm and 37 wt % lauric acid (LA), a phase change material, that acts as a heat-activable gatekeeper stopping or facilitating the abm release. When exposed to sunlight for 20 min at 1 and 3 sun light density, the temperature of the photothermal nanocarriers reaches 51 and 122 °C, respectively, which triggers the melting of LA and the consequent release of abm from the nanocarriers. Abm was shown to be released gradually over a period of 10 days when nanohybrids were exposed to sunlight for 6 h per day and to remain stable and kill Myzus persicae (Sulzer) (Hemiptera: Aphididae), green peach aphids, at a mortality rate of over 70% for at least 10 days. Aqueous dispersions of the LA/abm@HNT-PDA nanohybrids were studied in terms of their potential as aqueous sprayable pesticide nanoformulations and presented over 30% suspensibility, 36 mg/cm² foliar retention, strong rainwater resistance, and a 50% mortality rate for M. persicae at a concentration of 9 mg/mL. The proposed sunlight-activated controlled release system based on photothermal, LA-functionalized HNT-PDA nanocarriers holds great potential as controlled release pesticide nanoformulations.

SUBMITTER: Gundogdu SO

PROVIDER: S-EPMC10918824 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Pesticide Nanoformulations Based on Sunlight-Activated Controlled Release of Abamectin.

Gundogdu Selin Oyku SO Saglam Ozgur O Isikber Ali Arda AA Bozkurt Huseyin H Unal Hayriye H

ACS omega 20240220 9

A controlled release system that enables the sunlight-triggered release of a model agrochemical, abamectin (abm), is presented. The release system consists of polydopamine functionalized halloysite nanotubes (HNT-PDA) utilized as photothermal nanocarriers to encapsulate 25 wt % abm and 37 wt % lauric acid (LA), a phase change material, that acts as a heat-activable gatekeeper stopping or facilitating the abm release. When exposed to sunlight for 20 min at 1 and 3 sun light density, the temperatu ...[more]

PMID: 38463308

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Project description:Abstract: Controlled release of immunomodulatory cytokines like interleukin-4 (IL-4) from biomaterials can modulate host immune cell behavior to improve tissue integration, however options for modifying complex biomaterials remain limited. Bioconjugation strategies using biotin-avidin interactions offer a promising approach since biotin can be conjugated to proteins, biomaterials, and even cells, without compromising their function. Although it is known that conjugation of biotin to large biomolecules reduces its binding affinity for avidin and avidin variants, the potential to control release of biotinylated molecules via leveraging affinity interactions has not been thoroughly investigated. Moreover, the effects of biotin and avidin variants on innate immunity are poorly understood. Therefore, the goal of this study was to determine if biotin-avidin interactions could be manipulated to control the release of IL-4 from biomaterials and to investigate the subsequent effects on primary human macrophage phenotype. First, we characterized the effects of soluble biotin, avidin, and avidin variants, streptavidin and CaptAvidin, on the phenotype of primary human macrophages using RNA sequencing and found that CaptAvidin significantly influenced macrophage gene expression while other variants did not. Then, after evaluating how bioconjugation parameters influenced biotin density and avidin variant binding to porous gelatin scaffolds, we found that biotin-avidin affinity interactions influenced the spontaneous release of biotinylated IL-4 (bIL-4) from biotinylated and desthiobiotinylated scaffolds bound with either avidin or streptavidin for up to ten days in vitro. Finally, we measured the response of primary human macrophages (8 donors) cultured on modified scaffolds, finding an increase in IL-4 driven genes when bIL-4 was released via biotin-streptavidin affinity interactions compared to desorption-based release. These results highlight how biotin-avidin interactions can be leveraged for spontaneous release to achieve an immunomodulatory drug delivery system.

Dataset Information

Pesticide Nanoformulations Based on Sunlight-Activated Controlled Release of Abamectin.

Publications

Pesticide Nanoformulations Based on Sunlight-Activated Controlled Release of Abamectin.

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