Rituximab may affect T lymphocyte subsets balance in primary membranous nephropathy.

ABSTRACT:

Background

The aim of this study was to investigate the effects and significance of rituximab (RTX) on the levels of T lymphocyte subsets in patients diagnosed with primary membranous nephropathy (PMN).

Methods

A total of 58 PMN patients and 25 healthy donors were chosen as the subjects. Among the PMN patients, 40 individuals received RTX treatment and completed at least 6 months of follow-up. All subjects underwent flow cytometry analysis to determine the peripheral blood lymphocyte subsets. The changes in anti-PLA2R antibody titers and 24-hour urinary protein levels were evaluated by ELISA and Biuret method before and after treatment.

Results

(1) The PMN group exhibited a significantly greater percentage of peripheral blood CD3^-CD19⁺ B cells th

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10918849 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature