Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities.

ABSTRACT:

Background

Growing evidence suggests that not only cerebrovascular disease but also Alzheimer's disease (AD) pathological process itself cause cerebral white matter degeneration, resulting in white matter hyperintensities (WMHs). Some preclinical evidence also indicates that white matter degeneration may precede or affect the development of AD pathology. This study aimed to clarify the direction of influence between in vivo AD pathologies, particularly beta-amyloid (Aβ) and tau deposition, and WMHs through longitudinal approach.

Methods

Total 282 older adults including cognitively normal and cognitively impaired individuals were recruited from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) cohort. The participants underwent

SUBMITTER: Cha WJ 

PROVIDER: S-EPMC10918927 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature