Comparative analysis of the vaginal bacteriome and virome in healthy women living in high-altitude and sea-level areas.

ABSTRACT: The vaginal microbiota plays an important role in the health of the female reproductive tract and is closely associated with various pregnancy outcomes and sexually transmitted diseases. Plenty of internal and external factors have strong influence on the changes in a woman's vaginal microbiome. However, the effect of a high-altitude on female vaginal microbiota has not been described. In this study, we characterized the vaginal bacteriome and virome of 13 and 34 healthy women living in high-altitude and sea-level areas, using whole-metagenome shotgun sequencing of their vaginal mucus samples. The results revealed that the vaginal bacteriomes of high-altitude individuals are featured by a significant increase of species diversity, depletion of Lactobacillus crispatus, and more abundant of

SUBMITTER: Li C 

PROVIDER: S-EPMC10918948 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature