Differentiated adaptative genetic architecture and language-related demographical history in South China inferred from 619 genomes from 56 populations.

ABSTRACT:

Background

The underrepresentation of human genomic resources from Southern Chinese populations limited their health equality in the precision medicine era and complete understanding of their genetic formation, admixture, and adaptive features. Besides, linguistical and genetic evidence supported the controversial hypothesis of their origin processes. One hotspot case was from the Chinese Guangxi Pinghua Han people (GPH), whose language was significantly similar to Southern Chinese dialects but whose uniparental gene pool was phylogenetically associated with the indigenous Tai-Kadai (TK) people. Here, we analyzed genome-wide SNP data in 619 people from four language families and 56 geographically different populations, in which 261 people from 21 geographically distinct populations

SUBMITTER: Sun Q 

PROVIDER: S-EPMC10918984 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature