Impaired balance between neutrophil extracellular trap formation and degradation by DNases in COVID-19 disease.

ABSTRACT:

Background

Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpinning this dysregulation remain elusive. We hypothesised that lower DNase activity may be associated with higher NETosis and clinical worsening in patients with COVID-19.

Methods

Biological samples were obtained from hospitalized patients (15 severe, 37 critical at sampling) and 93 non-severe ambulatory cases. Our aims were to compare NET biomarkers, functional DNase levels, and explore mechanisms driving any imbalance concerning disease severity.

Results

Functional DNase levels were diminished in the most severe patients, paralleling an imbalance between NET markers and

SUBMITTER: Garcia G 

PROVIDER: S-EPMC10919029 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature