SNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese.

ABSTRACT:

Background

Drug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association between genetics and drug addiction among Han Chinese.

Methods

A total of 1000 Chinese users of illicit drugs and 9693 healthy controls were enrolled and underwent single nucleotide polymorphism (SNP)-based and haplotype-based association analyses via whole-genome genotyping.

Results

Both single-SNP and haplotype tests revealed associations between illicit drug use and several immune-related genes in the major histocompatibility complex (MHC) region (SNP association: log₁₀BF = 15.135, p = 1.054e-18; haplotype association: log₁₀BF = 20.925, p = 2.065e-24). These genes may affect the risk of drug addi

SUBMITTER: Xu H 

PROVIDER: S-EPMC10919046 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature