Divergent Learning-Related Transcriptional States of Cortical Glutamatergic Neurons.

ABSTRACT: Experience-dependent gene expression reshapes neural circuits, permitting the learning of knowledge and skills. Most learning involves repetitive experiences during which neurons undergo multiple stages of functional and structural plasticity. Currently, the diversity of transcriptional responses underlying dynamic plasticity during repetition-based learning is poorly understood. To close this gap, we analyzed single-nucleus transcriptomes of L2/3 glutamatergic neurons of the primary motor cortex after 3 d motor skill training or home cage control in water-restricted male mice. "Train" and "control" neurons could be discriminated with high accuracy based on expression patterns of many genes, indicating that recent experience leaves a widespread transcriptional signature across L2/3 neurons

SUBMITTER: Dunton KL 

PROVIDER: S-EPMC10919205 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature