Bayesian adaptive design for covariate-adaptive historical control information borrowing.

ABSTRACT: Interest in incorporating historical data in the clinical trial has increased with the rising cost of conducting clinical trials. The intervention arm for the current trial often requires prospective data to assess a novel treatment, and thus borrowing historical control data commensurate in distribution to current control data is motivated in order to increase the allocation ratio to the current intervention arm. Existing historical control borrowing adaptive designs adjust allocation ratios based on the commensurability assessed through study-level summary statistics of the response agnostic of the distributions of the trial subject characteristics in the current and historical trials. This can lead to distributional imbalance of the current trial subject characteristics across the treat

SUBMITTER: Jin H 

PROVIDER: S-EPMC10919261 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature