Characterization of glomerular basement membrane components within pediatric glomerular diseases.

ABSTRACT:

Background

Disruptions in gene expression associated with the glomerular basement membrane (GBM) could precipitate glomerular dysfunction. Nevertheless, a comprehensive understanding of the characterization of GBM components within pediatric glomerular diseases and their potential association with glomerular function necessitates further systematic investigation.

Methods

We conducted a systematic analysis focusing on the pathological transformations and molecular attributes of key constituents within the GBM, specifically Collagen IV α3α4α5, Laminin α5β2γ1, and Integrin α3β1, across prevalent pediatric glomerular diseases.

Results

We observed upregulation of linear expression levels of COL4A3/4/5 and Laminin 5α proteins, along with a partial reduction in the linear st

SUBMITTER: Chen D 

PROVIDER: S-EPMC10919337 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature