Waning effectiveness of mRNA COVID-19 vaccines against inpatient and emergency department encounters.

ABSTRACT: In the United States, most real-world estimates of COVID-19 vaccine effectiveness are based on data drawn from large health systems or sentinel populations. More data is needed to understand how the benefits of vaccination may vary across US populations with disparate risk profiles and policy contexts. We aimed to provide estimates of mRNA COVID-19 vaccine effectiveness against moderate and severe outcomes of COVID-19 based on state population-level data sources. Using statewide integrated administrative and clinical data and a test-negative case-control study design, we assessed mRNA COVID-19 vaccine effectiveness against SARS-CoV-2-related hospitalizations and emergency department visits among adults in South Carolina. We presented estimates of vaccine effectiveness at discrete time inte

SUBMITTER: Giannouchos TV 

PROVIDER: S-EPMC10919609 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature