The relationship between emotional disorders and heart rate variability: A Mendelian randomization study.

ABSTRACT:

Objective

Previous studies have shown that emotional disorders are negatively associated with heart rate variability (HRV), but the potential causal relationship between genetic susceptibility to emotional disorders and HRV remains unclear. We aimed to perform a Mendelian randomization (MR) study to investigate the potential association between emotional disorders and HRV.

Methods

The data used for this study were obtained from publicly available genome-wide association study datasets. Five models, including the inverse variance weighted model (IVW), the weighted median estimation model (WME), the weighted model-based method (WM), the simple model (SM) and the MR-Egger regression model (MER), were utilized for MR. The leave-one-out sensitivity test, MR pleiotropy residual su

SUBMITTER: Luo X 

PROVIDER: S-EPMC10919610 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature