Longitudinal MicroRNA Signature of Conversion to Psychosis.

ABSTRACT:

Background and hypothesis

The emergence of psychosis in ultra-high-risk subjects (UHR) is influenced by gene-environment interactions that rely on epigenetic mechanisms such as microRNAs. However, whether they can be relevant pathophysiological biomarkers of psychosis' onset remains unknown.

Study design

We present a longitudinal study of microRNA expression, measured in plasma by high-throughput sequencing at baseline and follow-up, in a prospective cohort of 81 UHR, 35 of whom developed psychosis at follow-up (converters). We combined supervised machine learning and differential graph analysis to assess the relative weighted contribution of each microRNA variation to the difference in outcome and identify outcome-specific networks. We then applied univariate models to the

SUBMITTER: Iftimovici A 

PROVIDER: S-EPMC10919777 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature