Clustering Schizophrenia Genes by Their Temporal Expression Patterns Aids Functional Interpretation.

ABSTRACT:

Background

Schizophrenia is a highly heritable brain disorder with a typical symptom onset in early adulthood. The 2-hit hypothesis posits that schizophrenia results from differential early neurodevelopment, predisposing an individual, followed by a disruption of later brain maturational processes that trigger the onset of symptoms.

Study design

We applied hierarchical clustering to transcription levels of 345 genes previously linked to schizophrenia, derived from cortical tissue samples from 56 donors across the lifespan. We subsequently calculated clustered-specific polygenic risk scores for 743 individuals with schizophrenia and 743 sex- and age-matched healthy controls.

Study results

Clustering revealed a set of 183 genes that was significantly upregulated prenata

SUBMITTER: van der Meer D 

PROVIDER: S-EPMC10919784 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature