Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer.

ABSTRACT:

Background and hypothesis

While the phenotypic association between schizophrenia and breast cancer has been observed, the underlying intrinsic link is not adequately understood. We aim to conduct a comprehensive interrogation on both phenotypic and genetic relationships between schizophrenia and breast cancer.

Study design

We first used data from UK Biobank to evaluate a phenotypic association and performed an updated meta-analysis incorporating existing cohort studies. We then leveraged genomic data to explore the shared genetic architecture through a genome-wide cross-trait design.

Study results

Incorporating results of our observational analysis, meta-analysis of cohort studies suggested a significantly increased incidence of breast cancer among women with schizoph

SUBMITTER: Tang M 

PROVIDER: S-EPMC10919785 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature