Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia.

ABSTRACT:

Background and hypothesis

Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia.

Study design

We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 7

SUBMITTER: Tsugawa S 

PROVIDER: S-EPMC10919786 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature