Vancomycin nephrotoxicity: A comprehensive clinico-pathological study.

ABSTRACT:

Introduction

Vancomycin, a commonly prescribed antibiotic particularly in the setting of multi-drug resistant infections, is limited by its nephrotoxicity. Despite its common occurrence, much remains unknown on the clinicopathologic profile as well as the pathogenesis of vancomycin nephrotoxicity. Clinical studies included patients often with severe comorbidities and concomitant polypharmacy confounding the causal pathogenesis. Animal models cannot recapitulate this complex clinical situation. Kidney biopsy was not commonly performed.

Methods

To address this limitation, we studied 36 patients who had renal biopsies for acute kidney injury (AKI) for suspicion of vancomycin nephrotoxicity. Detailed renal biopsy evaluation, meticulous evaluation of clinical profiles, and up-to-

SUBMITTER: Nachiappa Ganesh R 

PROVIDER: S-EPMC10919848 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature