Interactions between circuit architecture and plasticity in a closed-loop cerebellar system.

ABSTRACT: Determining the sites and directions of plasticity underlying changes in neural activity and behavior is critical for understanding mechanisms of learning. Identifying such plasticity from neural recording data can be challenging due to feedback pathways that impede reasoning about cause and effect. We studied interactions between feedback, neural activity, and plasticity in the context of a closed-loop motor learning task for which there is disagreement about the loci and directions of plasticity: vestibulo-ocular reflex learning. We constructed a set of circuit models that differed in the strength of their recurrent feedback, from no feedback to very strong feedback. Despite these differences, each model successfully fit a large set of neural and behavioral data. However, the patterns of

SUBMITTER: Payne HL 

PROVIDER: S-EPMC10919899 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature