Assessing the Causal Relationship between Genetically Determined Inflammatory Cytokines and Parkinson's Disease Risk: A Bidirectional Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Observational studies have suggested an association between inflammatory cytokines and Parkinson's disease (PD). This Mendelian randomization (MR) was conducted to further assess the causal correlations between inflammatory cytokines and PD.

Methods

Genetic instruments associated with inflammatory cytokines were extracted from a large summary genome-wide association studies (GWAS) involving 8,293 European participants. Summary-level statistics for PD were obtained from a large-sample GWAS containing 17 studies that involved European participants. Causalities of exposures and outcomes were explored mainly using inverse variance weighted (IVW) method.

Results

The IVW method indicated that basic fibroblast growth factor (FGFBasic), interleukin-2 (IL-2), and ma

SUBMITTER: Xue H 

PROVIDER: S-EPMC10919978 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature