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Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test.

ABSTRACT: Chronic pain occurs at epidemic levels throughout the population. Hypersensitivity to touch, is a cardinal symptom of chronic pain. Despite dedicated research for over a century, quantifying this hypersensitivity has remained impossible at scale. To address these issues, we developed the Chainmail Sensitivity Test (CST). Our results show that control mice spend significantly more time on the chainmail portion of the device than mice subject to neuropathy. Treatment with gabapentin abolishes this difference. CST-derived data correlate well with von Frey measurements and quantify hypersensitivity due to inflammation. Our study demonstrates the potential of the CST as a standardized tool for assessing mechanical hypersensitivity in mice with minimal operator input.

SUBMITTER: Ozdemir Y

PROVIDER: S-EPMC10920263 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test.

Ozdemir Yildirim Y Nakamoto Kazuo K Boivin Bruno B Bullock Daniel D Andrews Nick A NA González-Cano Rafael R Costigan Michael M

Frontiers in pharmacology 20240223

Chronic pain occurs at epidemic levels throughout the population. Hypersensitivity to touch, is a cardinal symptom of chronic pain. Despite dedicated research for over a century, quantifying this hypersensitivity has remained impossible at scale. To address these issues, we developed the Chainmail Sensitivity Test (CST). Our results show that control mice spend significantly more time on the chainmail portion of the device than mice subject to neuropathy. Treatment with gabapentin abolishes this ...[more]

PMID: 38464715

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Project description:Highlights • Movement-evoked pain is a reliable measure in people with shoulder pain.• Sensitivity to movement-evoked pain index derived from the studied MEP procedure is not a reliable measure in people with shoulder pain.• Other ways of assessing sensitivity to movement-evoked pain are warranted. Background The number of researchers and clinicians using movement-evoked pain and sensitivity to movement-evoked pain to assess shoulder pain has increased. However, the intrarater test-retest reliability of movement-evoked pain and sensitivity to movement-evoked pain in people with rotator cuff-related shoulder pain (RCRSP) is still unknown. Objective We examined the intrarater test-retest reliability of movement-evoked pain and sensitivity to movement-evoked pain in participants with RCRSP. Methods Seventy-four participants with RCRSP performed five trials of active shoulder abduction to elicit pain under two experimental conditions: active shoulder abduction to the onset of pain and maximum range of motion (ROM). The primary outcome measures were pain intensity and ROM. Test-retest reliability of movement-evoked pain and sensitivity to movement-evoked pain was examined using intraclass correlation coefficient (ICC3,1) and minimal detectable change (MDC90). Results The reliability of movement-evoked pain under both experimental conditions was good to excellent (ICC: 0.81 to 0.95), while the reliability of sensitivity to movement-evoked pain was poor in both conditions (ICC≤0.45). The MDC90 for pain intensity was 1.6 and 1.8 during shoulder abduction to the onset of pain and maximum ROM, respectively. The MDC90 for ROM was 17.5° and 11.2° during shoulder abduction to the onset of pain and maximum ROM condition, respectively. Conclusion This study confirms movement-evoked pain testing during active shoulder abduction to the onset of pain or maximum ROM condition is reliable to assess pain associated with movement in patients with RCRSP. The minimal detectable change score of movement-evoked pain can guide clinicians and researchers on how to interpret changes in these outcomes.

Dataset Information

Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test.

Publications

Quantification of stimulus-evoked tactile allodynia in free moving mice by the chainmail sensitivity test.

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