Subcutaneous anakinra in the management of refractory MIS-C in France.

ABSTRACT:

Introduction

Multisystemic inflammatory syndrome in children (MIS-C) is a therapeutic emergency and can lead to myocardial dysfunction (17%-75%) and heart failure (52%-53%). Intravenous immunoglobulins (IVIG) and corticosteroids (CST) have been validated for the management of this condition. Recent reports suggest that an interleukin-1 (IL-1) receptor antagonist, namely anakinra, may be a valuable add-on to the 2019 novel coronavirus disease (COVID-19) treatment for refractory patients. The purpose of this study was to describe the clinico-biological characteristics of patients treated with anakinra as well as the efficacy and safety of subcutaneous anakinra therapy in this condition.

Methods

The prospective multicentre study of children hospitalized for MIS-C between March

SUBMITTER: Dusser P 

PROVIDER: S-EPMC10920278 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature