Bioinformatics analysis and experimental validation of key genes associated with lumbar disc degeneration and biomechanics.

ABSTRACT:

Background

Lumbar disc degeneration (LDD) is an important pathological basis for the development of degenerative diseases of the lumbar spine. Most clinical patients have low back pain as their main symptom. The deterioration of the biomechanical environment is an important cause of LDD. Although there is a large amount of basic research on LDD, there are fewer reports that correlate biomechanical mechanisms with basic research. Our research aims to identify 304 key genes involved in LDD due to biomechanical deterioration, using a bioinformatics approach. We focus on SMAD3, CAV1, SMAD7, TGFB1 as hub genes, and screen for 30 potential target drugs, offering novel insights into LDD pathology and treatment options.

Methods

The Gene Cards, GenCLip3, OMIM and Drugbank databases w

SUBMITTER: Liu X 

PROVIDER: S-EPMC10920361 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature