Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults.

ABSTRACT:

Background

The study explores whether frailty at midlife predicts mortality and levels of biomarkers associated with Alzheimer's disease and related dementias (ADRD) and neurodegeneration by early old age. We also examine the heritability of frailty across this age period.

Methods

Participants were 1,286 community-dwelling men from the Vietnam Era Twin Study of Aging at average ages 56, 62 and 68, all without ADRD at baseline. The cumulative deficit frailty index (FI) comprised 37 items assessing multiple physiological systems. Plasma biomarkers at age 68 included beta-amyloid (Aβ40, Aβ42), total tau (t-tau) and neurofilament light chain (NfL).

Results

Being frail doubled the risk of all-cause mortality by age 68 (OR = 2.44). Age 56 FI significantly predicted age 68 N

SUBMITTER: Buchholz E 

PROVIDER: S-EPMC10921085 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature