Genotype-based precision nutrition strategies for the prediction and clinical management of type 2 diabetes mellitus.

ABSTRACT: Globally, type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders. T2DM physiopathology is influenced by complex interrelationships between genetic, metabolic and lifestyle factors (including diet), which differ between populations and geographic regions. In fact, excessive consumptions of high fat/high sugar foods generally increase the risk of developing T2DM, whereas habitual intakes of plant-based healthy diets usually exert a protective effect. Moreover, genomic studies have allowed the characterization of sequence DNA variants across the human genome, some of which may affect gene expression and protein functions relevant for glucose homeostasis. This comprehensive literature review covers the impact of gene-diet interactions on T2DM susceptibility and disease p

SUBMITTER: Ramos-Lopez O 

PROVIDER: S-EPMC10921165 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature