Unremitting pro-inflammatory T-cell phenotypes, and macrophage activity, following paediatric burn injury.

ABSTRACT:

Objectives

The aim of this study was to characterise the dynamic immune profile of paediatric burn patients for up to 18 months post-burn.

Methods

Flow cytometry was used to measure 25 cell markers, chemokines and cytokines which reflected both pro-inflammatory and anti-inflammatory immune profiles. Peripheral blood mononuclear cells from 6 paediatric burn patients who had returned for repeated burn and scar treatments for > 4 timepoints within 12 months post-burn were compared to four age-matched healthy controls.

Results

While overall proportions of T cells, NK cells and macrophages remained relatively constant, over time percentages of these immune cells differentiated into effector and proinflammatory cell phenotypes including Th17 and activated γδ T cells. Circul

SUBMITTER: Langley D 

PROVIDER: S-EPMC10921233 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature