Tanshinone IIA ameliorates energy metabolism dysfunction of pulmonary fibrosis using ¹³C metabolic flux analysis.

ABSTRACT: Evidence indicates that metabolic reprogramming characterized by the changes in cellular metabolic patterns contributes to the pathogenesis of pulmonary fibrosis (PF). It is considered as a promising therapeutic target anti-PF. The well-documented against PF properties of Tanshinone IIA (Tan IIA) have been primarily attributed to its antioxidant and anti-inflammatory potency. Emerging evidence suggests that Tan IIA may target energy metabolism pathways, including glycolysis and tricarboxylic acid (TCA) cycle. However, the detailed and advanced mechanisms underlying the anti-PF activities remain obscure. In this study, we applied [U-¹³C]-glucose metabolic flux analysis (MFA) to examine metabolism flux disruption and modulation nodes of Tan IIA in PF. We identified that Tan IIA in

SUBMITTER: Shan B 

PROVIDER: S-EPMC10921327 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature