Brucella abortus triggers the differential expression of immunomodulatory lncRNAs in infected murine macrophages.

ABSTRACT:

Introduction

The lncRNAs (long non-coding RNAs) are the most diverse group of non-coding RNAs and are involved in most biological processes including the immune response. While some of them have been recognized for their influence on the regulation of inflammatory activity, little is known in the context of infection by Brucella abortus, a pathogen that presents significant challenges due to its ability to manipulate and evade the host immune system. This study focuses on characterize the expression profile of LincRNA-cox2, Lethe, lincRNA-EPS, Malat1 and Gas5 during infection of macrophages by B. abortus.

Methods

Using public raw RNA-seq datasets we constructed for a lncRNA expression profile in macrophages Brucella-infected. In addition, from public RNA

SUBMITTER: Flores-Concha M 

PROVIDER: S-EPMC10921354 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature