Antigenic epitope targets of rhesus macaques self-curing from Schistosoma mansoni infection.

ABSTRACT: The self-cure of rhesus macaques from a schistosome infection and their subsequent strong immunity to a cercarial challenge should provide novel insights into the way these parasites can be eliminated by immunological attack. High-density arrays comprising overlapping 15-mer peptides from target proteins printed on glass slides can be used to screen sera from host species to determine antibody reactivity at the single epitope level. Careful selection of proteins, based on compositional studies, is crucial to encompass only those exposed on or secreted from the intra-mammalian stages and is intended to focus the analysis solely on targets mediating protection. We report the results of this approach using two pools of sera from hi- and lo-responder macaques undergoing self-cure, to screen ar

SUBMITTER: Vance GM 

PROVIDER: S-EPMC10921417 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature