Transplantation of human neural stem cell prevents symptomatic motor behavior disability in a rat model of Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is a ubiquitous brain cell degeneration disease and presents a significant therapeutic challenge. By injecting 6-hydroxydopamine (6-OHDA) into the left medial forebrain bundle, rats were made to exhibit PD-like symptoms and treated by intranasal administration of a low-dose (2 × 10⁵) or high-dose (1 × 10⁶) human neural stem cells (hNSCs). Apomorphine-induced rotation test, stepping test, and open field test were implemented to evaluate the motor behavior and high-performance liquid chromatography was carried out to detect dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin, and 5-hydroxyindole-3-acetic acid in the striatum of rats. Animals injected with 6-OHDA showed significant motor function deficits and damaged dopaminergic sys

SUBMITTER: Wang F 

PROVIDER: S-EPMC10921471 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature